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c/retatrutide·submitted 6 months ago by u/yara_lindholm

what changed for me between week 30 and week 79

Questionbranch of 8 comments

Week 43 update. 19kg down from the start, early fullness basically gone since about week 83. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness. The part that surprised me is how much of this is…

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8 comments, started 6 months ago
u/emil_agyeman135 points·6 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/lina_bruun31 points·6 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/zeynep_mbeki73 points·6 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/mateusz_mensah76 points·6 months ago

This is correct. Triple agonism is genuinely different.

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u/deleted_my_history51 points·6 months ago

Not convinced. The evidence does not support that reading.

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u/soren_nkemelu21 points·6 months ago

Not convinced.

Yes, exactly this, and it is the bit that took me 72 weeks to accept.

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u/incretin_ivypharmacology30 points·6 months ago

the glucagon component changes the side effect profile, not just the efficacy

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u/baseline_drifteranalytical66 points·6 months ago

Not convinced. The evidence does not support that reading.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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