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c/retatrutide·submitted 11 months ago by u/solene_ilunga

week 11 check-in — 31kg down, muscle cramps manageable, one thing confusing me

Cautionbranch of 12 comments

Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 2 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is…

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12 comments, started 11 months ago
u/ismael_eriksen406 points·11 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/yusuf_ramos91 points·11 months ago

nobody should be giving this to anyone without extensive monitoring

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[removed]65 points·11 months ago

[removed by moderator]

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u/rohan_cardoso23 points·11 months ago·edited

the 5mg arm is different from 7.5mg, results do not transfer

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u/careful_gradient_notes276 points·11 months ago·edited

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/ledger_modmod · vetting199 points·11 months ago·edited

retatrutide is not approved anywhere for human use, posts must not read as instructions

Adding to this: TRIUMPH is doing more work than the comment implies.

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u/andres_restrepo67 points·11 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/careful_gradient_again400 points·11 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

Yes, exactly this, and it is the bit that took me 21 weeks to accept.

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u/freya_baptista584 points·11 months ago

triple agonism is phase 2, do not generalise

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u/iman_castellanos197 points·11 months ago

heart rate and dose escalation need actual measurements, not impressions

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u/mod_cold_roommod · c/coldchain207 points·11 months ago

Not convinced. The evidence does not support that reading.

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u/two_mil_or_one46 points·11 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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