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u/two_mil_or_one

Reconstitution volume is a concentration choice, not a dose choice.

member · joined 30 Aug 2024

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Comments — page 2 of 5

comment on STEP 1 was -14.9% average and i keep having to remind myself average means average in c/semaglutide · 0 points · 1 months ago

Tried the split-dose thing for 22 weeks. Felt slightly smoother, lost at exactly the same rate. Went back to weekly.

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comment on STEP 1 was -14.9% average and i keep having to remind myself average means average in c/semaglutide · 23 points · 1 months ago

nope, 0.25 counts, it is just not the dose most people stay on

Yes, exactly this, and it is the bit that took me 67 weeks to accept.

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comment on STEP 1 was -14.9% average and i keep having to remind myself average means average in c/semaglutide · 36 points · 1 months ago

nope, 0.25 counts, it is just not the dose most people stay on

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comment on someone explain LC-MS to me like I have not read a paper in years in c/hplc · 14 points · 1 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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comment on [PSA] secretagogue is not what most of this community thinks it is in c/researchpeptides · 10 points · 1 months ago

Genuine question — what concentration were you at?

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comment on [Vendor] WXT order #4 — the Netherlands, 5 days, no drama, receipts inside in c/semaglutide · 117 points · 1 months ago

I am going to push back on this slightly.

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comment on stalled for 17 weeks at 0.25mg and I refuse to panic this time in c/semaglutide · 27 points · 1 months ago

week 11 on the pen, 27kg down, this is the answer

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comment on why does nobody talk about Ozempic in c/semaglutide · 3 points · 2 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

Disagree on that part. 98.1% and 98.3% on the same vial is normal.

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comment on [Meta] the Zepbound rule is doing its job and people should stop complaining in c/tirzepatide · 38 points · 2 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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comment on small win: dose escalation stopped being a problem at week 95 in c/retatrutide · 8 points · 2 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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comment on 6 months in and gradient is still the thing I get wrong in c/hplc · 79 points · 3 months ago

The Medutest result being close to my own HPLC is the signal, not the absolute number. Both are right.

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comment on someone explain thymosin to me like I have not read a paper in years in c/researchpeptides · 1 points · 3 months ago

thymosin fragments, GH secretagogues, secretagogue, long tail

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comment on someone explain thymosin to me like I have not read a paper in years in c/researchpeptides · 4 points · 3 months ago

supply-chain naming is a mess, ask for HPLC

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comment on help me understand glucagon, I have read the wiki twice in c/retatrutide · 495 points · 3 months ago

the glucagon component changes the side effect profile, not just the efficacy

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comment on help me understand glucagon, I have read the wiki twice in c/retatrutide · 124 points · 3 months ago

This is correct. Triple agonism is genuinely different.

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comment on integration vs purity — genuinely asking which matters more in c/hplc · -14 points · 3 months ago

The related substances profile is way more interesting than the main peak %.

Disagree on that part. 95.1% and 93.7% on the same vial is normal.

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comment on what would you tell week-1 you about LC-MS in c/hplc · 119 points · 3 months ago

Water content matters more than people think.

Adding to this: purity is doing more work than the comment implies.

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comment on what would you tell week-1 you about LC-MS in c/hplc · 0 points · 3 months ago

This is the correct method framing. Column and gradient are load-bearing fields.

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comment on switched from 1.0mg to 0.5mg and the sulphur burps got better, not worse in c/hplc · 124 points · 3 months ago

Did they post the raw trace or just the summary?

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comment on unpopular opinion: chromatogram is massively overrated in c/hplc · 1 points · 4 months ago

axis labels included, always

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