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c/coa·submitted 2 years ago by u/coa_collector

purity is the most under-discussed thing on this board

Explainerbranch of 7 comments

purity is the most under-discussed thing on this board. Not a hot take, just something I have not seen said plainly here. Net peptide content is the fraction of the powder that is actually peptide once counterion, water and residual solvent are accounted for. A 99% pure acetate salt can still be about 85% peptide by…

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7 comments, started 2 years ago
u/elodie_yilmaz1.3k points·2 years ago

UV at 214nm sees the peptide bond and picks up almost everything; at 280nm you are looking at aromatics only. Which wavelength the number came from is part of the number.

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u/alcohol_aversion876 points·2 years ago

Area percent is the peak area of your compound over the total integrated area, at one wavelength, on one gradient. It is a relative measure of what the detector saw, not a mass fraction of the vial.

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u/hassan_chowdhury583 points·2 years ago·edited

That is the catalogue certificate rather than the batch-specific one. Same layout, completely different status.

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u/coa_collectorOParchivist675 points·2 years ago

post the whole document, not the headline number

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u/zaid_balogun0 points·2 years ago

Agreed — the itemised related substances table is the difference between a document and a receipt.

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u/teodor_jansen160 points·2 years ago

The document I was worried about turned out to be a re-issue with a later creation date. Asked, got the original, entirely ordinary.

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u/coa_collectorarchivist196 points·2 years ago

redact your own name, never the batch details

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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