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c/coldchain·posted 3 months ago by u/transit_variance

tried lyophilised for 3 weeks. here is what happened.

Data Clean Column ×1

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking data logger against eGFR for 3 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

871 up / 142 down86% upvoted36 commentsid 1s3vk816 Apr 2026

36 comments

13 in this archive, depth 4

best — the order this archive was captured in

u/mod_cold_roomMOD104 points·3 months ago

Retitled to remove editorialising. Put the evidence in the body.

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[deleted]74 points·3 months ago

[deleted]

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u/noor_cardoso61 points·3 months ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/ewan_tulloch49 points·3 months ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

Adding to this: lyophilised is doing more work than the comment implies.

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u/intent_to_treat25 points·3 months ago

Logger trace from my shipment: 15 hours at 11°C. Powder tested 99.1% against 93.7% claim. Tolerates more than the box implies.

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u/nadia_kjaer17 points·3 months ago·edited

France to France takes 17 days on average, variance is 19 days

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u/phase_two_pete6 points·3 months ago

excursion claims need a logger trace or a photo at unboxing, not "it felt warm"

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u/transit_variance31 points·3 months ago

Strongly agree. Peak temperature is not the whole story.

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u/appeal_letter_al49 points·3 months ago

This is correct. Dry powder is way more robust than liquid.

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u/honest_syringe3359 points·3 months ago

Not convinced. The evidence does not support that reading.

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u/preservative_free_p14 points·3 months ago

excursion claims need a logger trace or a photo at unboxing, not "it felt warm"

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u/gustav_vermeulen32 points·3 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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  1. Excursion claims need a logger trace or a photo taken at unboxing. "It felt warm" is not data.
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