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c/coldchain·submitted 11 months ago by u/marta_ilunga

reading stability threads from 2024 and half of it aged badly

Databranch of 7 comments

Genuinely asking, not being difficult. Everyone in c/compounding repeats that stability is important. I believe it, but I have never seen anyone show why, and when I search I get 3 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because…

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7 comments, started 11 months ago
u/ice_pack_auditcold chain77 points·11 months ago

This is correct. Dry powder is way more robust than liquid.

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u/transit_variance51 points·11 months ago

Reconstituted or dry powder?

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u/gustav_vermeulen41 points·11 months ago

Yeah, data logger is the only acceptable proof.

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u/chidi_yilmaz12 points·11 months ago

Disagree. What you are describing is consistent with lyophilised, not with what you concluded.

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u/marta_ilungaOP6 points·11 months ago

The gel pack lasted 5 hours in a courier van, then liquid. Powder itself fine, the cold chain mostly died in transit.

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u/osman_brandt1 point·11 months ago

excursion claims need a logger trace or a photo at unboxing, not "it felt warm"

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u/nightowl_injector37 points·11 months ago

This is correct.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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