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c/coldchain·posted 2 months ago by u/sten_palacios

stability — my 7-week log, condensed into one table

Data Well Actually ×7

Posting this because I searched for it and got nothing useful.

Setup: 1.0mg, week 85, sulphur burps present but not ruining anything. I changed exactly one variable — cold chain — and tracked it for 7 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

502 up / 160 down76% upvoted21 commentsid 1uvrl624 May 2026

21 comments

21 in this archive, depth 5

best — the order this archive was captured in

u/ice_pack_auditMOD51 points·2 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/curious_panel_only25 points·2 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/kenji_demir36 points·2 months ago·edited
this should be in the wiki
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[deleted]13 points·2 months ago

[deleted]

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u/marit_laurent19 points·2 months ago

The gel pack lasted 18 hours in a courier van, then liquid. Powder itself fine, the cold chain mostly died in transit.

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u/kofi_ferreira6 points·2 months ago

France to France takes 10 days on average, variance is 26 days

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u/coldchain_karencold chain12 points·2 months ago

Strongly agree. Peak temperature is not the whole story.

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u/preservative_free_p14 points·2 months ago

Which carrier and route?

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u/appeal_letter_al8 points·2 months ago

no tracking numbers, no full addresses, no label photos — instant removal

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u/priya_guerrero10 points·2 months ago

Yeah, data logger is the only acceptable proof.

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u/sten_palaciosOP7 points·2 months ago

Logger trace from my shipment: 12 hours at 33°C. Powder tested 98.0% against 98.4% claim. Tolerates more than the box implies.

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u/sten_palaciosOP6 points·2 months ago

The gel pack lasted 19 hours in a courier van, then liquid. Powder itself fine, the cold chain mostly died in transit.

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u/milos_vestergaard2 points·2 months ago

gel packs last 17 hours, after that you are relying on the box itself

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u/usb_logger_ursula4 points·2 months ago

Denmark to Denmark takes 22 days on average, variance is 4 days

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u/coa_collectorarchivist2 points·2 months ago

Denmark to Denmark takes 22 days on average, variance is 4 days

Yes, exactly this, and it is the bit that took me 34 weeks to accept.

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u/sten_palaciosOP1 point·2 months ago

Denmark to Denmark takes 22 days on average, variance is 4 days Yes, exactly this, and it is the bit that took me 34 weeks to accept.

Yes, exactly this, and it is the bit that took me 28 weeks to accept.

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u/reship_roulette2 points·2 months ago

This is correct. Dry powder is way more robust than liquid.

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u/nayeli_iyer6 points·2 months ago

lyophilised powder is far more forgiving than reconstituted solution

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u/hamza_weiss0 points·2 months ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/sterile_field_steph1 point·2 months ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

Adding to this: stability is doing more work than the comment implies.

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u/split_dose_sceptic1 point·2 months ago

data logger is the standard, gut feeling is not

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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  1. Excursion claims need a logger trace or a photo taken at unboxing. "It felt warm" is not data.
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