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c/coldchain·posted 3 months ago by u/solene_abubakar

small win: stability stopped being a problem at week 85

Failure Clean Column ×8 Slow Clap ×1

Confession thread, sort of.

I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 19 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have constipation I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 24 reads it before doing the same thing.

1,276 up / 250 down84% upvoted16 commentsid 1vzt5f2 Apr 2026

16 comments

12 in this archive, depth 4

best — the order this archive was captured in

u/cesar_teixeira103 points·3 months ago

stability after excursion is not zero, it is dose-dependent

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u/sunday_shot_sal43 points·3 months ago

stability after excursion is not zero, it is dose-dependent

Disagree on that part. 95.1% and 99.2% on the same vial is normal.

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u/honest_syringe3358 points·3 months ago
controversial sort brought me here and it was worth it
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u/solene_abubakarOP43 points·3 months ago

Logger trace from my shipment: 8 hours at 25°C. Powder tested 98.0% against 99.1% claim. Tolerates more than the box implies.

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[removed]16 points·3 months ago

[removed by moderator]

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u/marit_laurent29 points·3 months ago

lyophilised powder is far more forgiving than reconstituted solution

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u/kofi_ferreira7 points·3 months ago

Yeah, data logger is the only acceptable proof.

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u/ewan_tulloch41 points·3 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/spain_receta25 points·3 months ago

time-at-temperature integral is the dose, not just peak temperature

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u/solene_abubakarOP19 points·3 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/ines_lindqvist6 points·3 months ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/cato_batista9 points·3 months ago

time-at-temperature integral is the dose, not just peak temperature

Adding to this: excursion is doing more work than the comment implies.

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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c/coldchain rules
  1. Excursion claims need a logger trace or a photo taken at unboxing. "It felt warm" is not data.
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