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c/coldchain·posted 1 months ago by u/chidi_yilmaz

my A1c moved and I cannot work out whether ice pack is why

Failure Well Actually ×6 Cold Box ×2

Quick one. Canada here.

data logger works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.

Specifics: the route I used took 16 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.

Happy to answer questions from anyone in the same jurisdiction.

4,038 up / 2,941 down58% upvoted61 commentsid t5laxj13 Jun 2026

61 comments

23 in this archive, depth 4

best — the order this archive was captured in

u/hugo_bergstrom-32 points·1 months ago

This is correct. Dry powder is way more robust than liquid.

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u/source_or_silence148 points·1 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/niels_yilmaz73 points·1 months ago

Peak temperature and how long at that temperature?

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u/bence_ibarra57 points·1 months ago·edited

lyophilised powder is far more forgiving than reconstituted solution

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[deleted]25 points·1 months ago

[deleted]

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u/low_appetite_lisa67 points·1 months ago

The gel pack lasted 13 hours in a courier van, then liquid. Powder itself fine, the cold chain mostly died in transit.

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u/milos_vestergaard21 points·1 months ago·edited

time-at-temperature integral is the dose, not just peak temperature

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u/analog_alphabet0 points·1 months ago

lane reports need origin, destination, carrier, and actual transit days

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u/vito_chowdhury1 point·1 months ago

This is correct. Dry powder is way more robust than liquid.

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u/emeka_beaulieu1 point·1 months ago

Reconstituted or dry powder?

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u/prior_auth_painappeals1 point·1 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/kian_solberg56 points·1 months ago

Strongly agree. Peak temperature is not the whole story.

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u/nayeli_iyer45 points·1 months ago·edited

Strongly agree.

Adding to this: stability is doing more work than the comment implies.

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u/iman_castellanos29 points·1 months ago

Strongly agree.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/lina_almeida46 points·1 months ago·edited

customs clearance often breaks the cold chain, factor that in

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u/isabela_nilsen20 points·1 months ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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u/niels_norgaard16 points·1 months ago

Customs clearance took 7 days. Package sat unrefrigerated during that. Powder tested clean after, reconstituted solution probably would not have.

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u/runa_wikstrom7 points·1 months ago

data logger is the standard, gut feeling is not

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u/chidi_yilmazOP5 points·1 months ago

France to France: 6 days with WXT and 39 days with HJ. Same route, different carriers, variance is real.

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u/iman_castellanos6 points·1 months ago

Reconstituted or dry powder?

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u/anders_karlsen4 points·1 months ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/niels_yilmaz2 points·1 months ago

Denmark to Denmark takes 12 days on average, variance is 14 days

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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