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c/retatrutide·posted 8 months ago by u/viktor_laurent

small win: triple agonist stopped being a problem at week 61

Discussion Well Actually ×2 Sourced ×1 Clean Column ×1

Quick one. Canada here.

glucagon works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.

Specifics: the route I used took 8 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.

Happy to answer questions from anyone in the same jurisdiction.

7,527 up / 2,703 down74% upvoted20 commentsid ty0yf14 Nov 2025

20 comments

16 in this archive, depth 5

best — the order this archive was captured in

u/jarno_cabrera1k points·8 months ago
post the spreadsheet
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u/reta_and_regretMOD549 points·8 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/viktor_laurentOP325 points·8 months ago

heart rate and dose escalation need actual measurements, not impressions

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u/nausea_notesside effects270 points·8 months ago

the 12.5mg arm is different from 5mg, results do not transfer

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u/liver_enzyme_liz217 points·8 months ago·edited

the dosing is steep, the constipation reports are real, and nobody knows the human safety yet

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u/viktor_laurentOP589 points·8 months ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/tired_ledger_notes134 points·8 months ago

research use only, handling and analysis, not protocols

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u/viktor_laurentOP68 points·8 months ago

Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.

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u/crosspost_bot_no50 points·8 months ago·edited

This is correct. Triple agonism is genuinely different.

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u/customs_seizure_sid782 points·8 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/anya_moreau355 points·8 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

Adding to this: TRIUMPH is doing more work than the comment implies.

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u/ewan_zielinski323 points·8 months ago

research use only, handling and analysis, not protocols

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u/yannick_barros504 points·8 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/nadia_norgaard341 points·8 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/fabio_lehtinen128 points·8 months ago

the weight curves are unusually steep, which makes predicting individual response harder

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
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