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c/compounding·posted 1 year ago by u/priya_palacios

[Discussion] can we stop arguing about compounding until somebody posts a number

Discussion Receipts ×4

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking telehealth against eGFR for 19 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

640 up / 175 down78% upvoted24 commentsid 1n4ych21 Mar 2025

24 comments

16 in this archive, depth 5

best — the order this archive was captured in

u/liv_vukovic37 points·1 year ago

the shortage list is temporary, it ends and compounding becomes illegal again

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u/hamza_serrano19 points·1 year ago

Strongly agree. API source transparency matters.

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u/tobias_vukovic19 points·1 year ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/ahmed_fonseca23 points·1 year ago

Half-life is about 168 hours, so steady state lands around week 20–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/rafael_ostergaard12 points·1 year ago
nope. mine was the opposite.
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u/quiet_moderatorMOD7 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/mikkel_correia7 points·1 year ago

Mechanistically the bit that matters is telehealth. It explains most of the early profile and a decent chunk of the outcome.

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u/naomi_erdogan2 points·1 year ago

Asked 19 compounders about API source. One told me, one dodged, one said they cannot say. The answer is the signal.

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u/priya_palaciosOP1 point·1 year ago

Asked 24 compounders about API source. One told me, one dodged, one said they cannot say. The answer is the signal.

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u/dario_stanescu1 point·1 year ago

telehealth costs state board plus compounding markup, total varies

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u/ahmed_fonseca1 point·1 year ago

telehealth costs state board plus compounding markup, total varies

Yes, exactly this, and it is the bit that took me 80 weeks to accept.

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u/solene_eriksen7 points·1 year ago

The 503A pharmacy I used lost their shortage list eligibility. Same day, compounding became illegal. Rules are real.

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u/camila_mensa5 points·1 year ago

Yeah, 503A and 503B are different regulatory animals.

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u/draw_up_dizzy3 points·1 year ago

telehealth costs telehealth plus compounding markup, total varies

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u/discount_math_dm-3 points·1 year ago

Yeah, 503A and 503B are different regulatory animals.

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u/quiet_moderatormod2 points·1 year ago

the 503A/503B distinction is load-bearing, do not blur it

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About c/compounding

Compounded GLP-1s as a supply route: the 503A/503B distinction, the shortage-list mechanics that made compounding legal and then didn't, state board rules, telehealth prescriber models, and what a compounding pharmacy will and will not tell you about its API source.

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