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c/glp1science·submitted 15 days ago by u/brigade_detector

[Explainer] steady state at 4–5 weeks, and what that means for your titration

Explainerbranch of 5 comments

incretin. That is the whole post, but I will justify it. Everything else people worry about in c/intlshipping is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort incretin out first, and almost nobody does. I say this having got it wrong for 5 months. My…

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5 comments, started 14 days ago
u/milan_mensah2 points·14 days ago

Strongly agree. Central appetite is real but people overstate it.

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[deleted]1 point·14 days ago

[deleted]

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u/bastian_ekstrom1 point·14 days ago

the half-life is appetite, affects steady state timing

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u/lurker_for_years1 point·14 days ago·edited

Not to be pedantic but mechanism and pharmacology are being used interchangeably and they are not interchangeable in real life.

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u/brigade_detectorOP1 point·14 days ago

the half-life is appetite, affects steady state timing

Adding to this: mechanism is doing more work than the comment implies.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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