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c/glp1science·submitted 12 days ago by u/tomas_broberg

[Speculation] is the food-noise effect central, peripheral, or both

Speculationbranch of 5 comments

Week 67 update. 43kg down from the start, reflux basically gone since about week 24. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux. The part that surprised me is how much of this is admin. Ordering,…

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5 comments, started 11 days ago
u/ismael_chukwu9 points·11 days ago

Not convinced. The evidence does not support that reading.

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u/employer_carveout4 points·11 days ago

cite the paper: journal, year, first author, links optional

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u/sig_figs_sammod · analytical1 point·11 days ago

cite the paper: journal, year, first author, links optional

Disagree on that part. 99.2% and 99.3% on the same vial is normal.

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u/farid_kuipers1 point·11 days ago

Yeah, the incretin mechanism is doing the work here.

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u/aa_analysis_andy3 points·11 days ago·edited

the 23-day half-life means week 23 is still ramp-up pharmacokinetically

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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