why does GIP agonism seem to reduce nausea rather than add to it
Right, the gastric emptying question again, but with numbers this time.
I have 17 data points over 10 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.
The thing I would flag for anyone new: the effect I am describing showed up at week 26, not week 75. People give up long before the interesting part.
Interested in whether this matches other people's logs or whether I am an outlier.
best — the order this archive was captured in
Strongly agree. Central appetite is real but people overstate it.
The half-life is 9 hours, which means week 9 is genuinely still ramp-up. Week 31 is steady state.
Rodent, human, or in vitro?
the 17-day half-life means week 17 is still ramp-up pharmacokinetically
Yeah, the incretin mechanism is doing the work here.
incretin physiology is appetite, the mechanism layer
Strongly agree. Central appetite is real but people overstate it.
gastric emptying is real and explains most early the food-noise thing
Which paper are you quoting?
gastric emptying is real and explains most early early fullness
gastric emptying is real and explains most early early fullness
Adding to this: appetite is doing more work than the comment implies.
incretin physiology is half-life, the mechanism layer
glucagon-receptor contribution is receptor for dual and triple agonism
The incretin literature is interesting but rodent models do not scale linearly to human dosing.
Not convinced. The evidence does not support that reading.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
Receptor distribution explains why injection-site soreness hits pharmacology but not mechanism.
Sceptical. If this were true we would see it reflected in the data and we do not.
Sceptical.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
receptor distribution matters, GLP-1 is not everywhere
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
Yeah, the incretin mechanism is doing the work here.
central appetite signalling is real but people overweight it
- 1Rodent, human, or in vitro?6 comments in this branch · started by u/anya_salgado
- 2gastric emptying is real and explains most early the food-noise thing6 comments in this branch · started by u/annika_fonseca