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Single comment threadYou are looking at one branch of anyone else notice mechanism kicking in around week 70 — 18 comments in the full submission. View in context.
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c/glp1science·submitted 1 year ago by u/split_dose_sceptic

anyone else notice mechanism kicking in around week 70

Questionbranch of 6 comments

Trying to settle this properly because the thread from last year went in circles. The claim: mechanism matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything. What would actually settle it is 7 people measuring the same…

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6 comments, started 1 year ago
u/emeka_chowdhury-15 points·1 year ago

Is that mechanism or speculation?

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u/camila_kowalski1 point·1 year ago

cite the paper: journal, year, first author, links optional

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u/katrin_marchetti1 point·1 year ago

Small correction: the trial was 3 weeks, not 32. Does not change your point but people will quote it.

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u/rafael_ostergaard1 point·1 year ago

mechanistic speculation is welcome if flaired as speculation

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u/emeka_chowdhury1 point·1 year ago

Slight fix: the number was 96.8, not 99.1. Decimal point, but a fairly consequential one.

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[deleted]1 point·1 year ago

[deleted]

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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