anyone else notice mechanism kicking in around week 70
Trying to settle this properly because the thread from last year went in circles.
The claim: mechanism matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything.
What would actually settle it is 7 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
Is that mechanism or speculation?
cite the paper: journal, year, first author, links optional
Small correction: the trial was 3 weeks, not 32. Does not change your point but people will quote it.
mechanistic speculation is welcome if flaired as speculation
Slight fix: the number was 96.8, not 99.1. Decimal point, but a fairly consequential one.
Respectfully this is a sample of one presented as a finding.
the 15-day half-life means week 15 is still ramp-up pharmacokinetically
incretin physiology is receptor, the mechanism layer
Sceptical. If this were true we would see it reflected in the data and we do not.
This is correct. Rodent data is investigational, not predictive.
- 1Is that mechanism or speculation?6 comments in this branch · started by u/emeka_chowdhury
- 2Respectfully this is a sample of one presented as a finding.5 comments in this branch · started by u/rafael_ostergaard