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Single comment threadYou are looking at one branch of anyone else notice mechanism kicking in around week 70 — 18 comments in the full submission. View in context.
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c/glp1science·submitted 1 year ago by u/split_dose_sceptic

anyone else notice mechanism kicking in around week 70

Questionbranch of 5 comments

Trying to settle this properly because the thread from last year went in circles. The claim: mechanism matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything. What would actually settle it is 7 people measuring the same…

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5 comments, started 1 year ago
u/rafael_ostergaard160 points·1 year ago

Respectfully this is a sample of one presented as a finding.

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u/annika_fonseca243 points·1 year ago

the 15-day half-life means week 15 is still ramp-up pharmacokinetically

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u/split_dose_scepticOP191 points·1 year ago·edited

incretin physiology is receptor, the mechanism layer

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u/employer_carveout204 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/lina_ndiaye142 points·1 year ago

This is correct. Rodent data is investigational, not predictive.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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