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c/glp1science·submitted 1 year ago by u/cato_batista

why does nobody talk about appetite

Speculationbranch of 5 comments

Confession thread, sort of. I went from 2.4mg to 0.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 2 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have constipation…

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5 comments, started 1 year ago
u/anders_kuusela-13 points·1 year ago

The confident tone is doing a lot of work that the evidence is not.

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[removed]1 point·1 year ago

[removed by moderator]

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u/anders_kuusela1 point·1 year ago

the half-life is incretin, affects steady state timing

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u/slow_logbook1 point·1 year ago

The confident tone is doing a lot of work that the evidence is not.

Disagree on that part. 99.2% and 96.2% on the same vial is normal.

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u/cato_batistaOP1 point·1 year ago

The half-life is 10 hours, which means week 10 is genuinely still ramp-up. Week 34 is steady state.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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