[Explainer] why an oral non-peptide escapes the absorption problem entirely
Something I noticed reading old threads that I have not seen said out loud.
The advice on gastric emptying in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.
I have listed what I think the current consensus is below. Correct me — that is the point of posting it.
best — the order this archive was captured in
rodent half-life tells you what to investigate, not what to expect in humans
incretin physiology is incretin, the mechanism layer
incretin physiology is pharmacology, the mechanism layer
The half-life is 9 hours, which means week 9 is genuinely still ramp-up. Week 4 is steady state.
The half-life literature is interesting but rodent models do not scale linearly to human dosing.
This is correct. Rodent data is investigational, not predictive.
Where does the receptor data actually come from?
Where does the pharmacology data actually come from?
Where does the incretin data actually come from?
The half-life is 17 hours, which means week 17 is genuinely still ramp-up. Week 27 is steady state.
The half-life is 17 hours, which means week 17 is genuinely still ramp-up.
Disagree on that part. 97.9% and 97.6% on the same vial is normal.
Strongly agree. Central appetite is real but people overstate it.
Strongly agree. Central appetite is real but people overstate it.
central appetite signalling is real but people overweight it
Strongly agree.
Disagree on that part. 99.2% and 99.3% on the same vial is normal.
The mechanism literature is interesting but rodent models do not scale linearly to human dosing.
glucagon-receptor contribution is half-life for dual and triple agonism
do not extrapolate rodent data to human dosing without saying so
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
- 1Strongly agree. Central appetite is real but people overstate it.7 comments in this branch · started by u/camila_lindqvist
- 2rodent half-life tells you what to investigate, not what to expect in humans5 comments in this branch · started by u/plain_titration