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biased agonism: real, interesting, almost certainly irrelevant to your dose
Long-ish post, sorry. tl;dr at the bottom. I have been tracking incretin against ApoB for 33 weeks because I could not find anyone who had. The correlation is weaker…
u/hassan_ostergaard
Contributes reviews on supplier material. Based in Mysuru.
member · joined 18 Sep 2025
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comment on [Results] A1c 9.1 → 5.4, full table, 14 months in c/t2dglp1 · 47 points · 1 days ago
the 75 A1c trend is the answer
comment on [Caution] stacking with a sulfonylurea is a real hypo risk, not a theoretical one in c/t2dglp1 · 35 points · 2 days ago
My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.
comment on [Results] A1c 9.1 → 5.4, full table, 14 months in c/t2dglp1 · 29 points · 2 days ago
the fasting insulin change is the signal
comment on TB-500 and Thymosin Beta-4 are not the same product and vendors know that in c/researchpeptides · 4 points · 2 days ago
research use only, handling and analysis, not administration
comment on week 2 and literally nothing has happened, is this normal in c/semaglutide · 14 points · 6 days ago
How long were you at 5mg before you moved up?
comment on [Question] A1c 5.6 but CGM says otherwise. which do i believe. in c/t2dglp1 · 22 points · 15 days ago
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
comment on [Struggle] eight weeks, 2kg, doing everything right, and it is grinding me down in c/progresspics · 27 points · 23 days ago
5 months, 23kg, progress
comment on [Explainer] why an oral non-peptide escapes the absorption problem entirely in c/glp1science · 16 points · 24 days ago
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
comment on [Discussion] we underplay how much of the GI stuff is dose-escalation speed in c/sideeffects · 1 points · 24 days ago
IANAD and neither is anyone upvoting this
comment on three years of A1c threads, summarised so you do not have to read them in c/t2dglp1 · 18 points · 26 days ago
metformin combo is standard
comment on sunday night injection, 61 weeks straight, ask me anything boring in c/semaglutide · 22 points · 26 days ago
titration speed is weekly dosing plus side effects, period
comment on biased agonism: real, interesting, almost certainly irrelevant to your dose in c/glp1science · 6 points · 29 days ago
The half-life is 24 hours, which means week 24 is genuinely still ramp-up. Week 4 is steady state.
comment on biased agonism: real, interesting, almost certainly irrelevant to your dose in c/glp1science · 11 points · 29 days ago
central appetite signalling is real but people overweight it
comment on does anyone else get one good week and one flat week on repeat in c/semaglutide · 1 points · 1 months ago
Slight fix: the number was 96.8, not 99.0. Decimal point, but a fairly consequential one.
comment on anyone else notice research peptides kicking in around week 9 in c/researchpeptides · 71 points · 1 months ago
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
comment on stalled for 14 weeks at 5mg and I refuse to panic this time in c/sideeffects · 16 points · 1 months ago
sulphur burps are disgusting but not dangerous, 3 weeks and they stopped
comment on [Side Effects] the sulphur burps are real and they do pass in c/semaglutide · 20 points · 1 months ago
my ApoB moved before the scale did and i nearly missed it
comment on France: pharmacology, and what it actually costs here in c/glp1science · 208 points · 1 months ago
Not to be pedantic but receptor and incretin are being used interchangeably and they are not interchangeable in real life.
comment on clothes fit the same for 14 months and it is genuinely strange in c/maintenancephase · 8 points · 1 months ago
food noise returns but not always immediately