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c/semaglutide·posted 28 days ago by u/ffmi_watcher

sunday night injection, 61 weeks straight, ask me anything boring

Titration

Posting this because I searched for it and got nothing useful.

Setup: 0.5mg, week 15, injection-site soreness present but not ruining anything. I changed exactly one variable — weekly dosing — and tracked it for 4 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

305 up / 87 down78% upvoted25 commentsid 1cxyrf1 Jul 2026

25 comments

18 in this archive, depth 6

best — the order this archive was captured in

u/aleksi_grimaldi29 points·28 days ago·edited

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/quiet_moderatorMOD15 points·28 days ago·edited

Retitled to remove editorialising. Put the evidence in the body.

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u/customs_seizure_sid12 points·28 days ago·edited

Slight fix: the number was 97.2, not 97.4. Decimal point, but a fairly consequential one.

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u/quiet_moderatormod10 points·27 days ago

the quiet is real. the food noise just stops.

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u/yara_boateng28 points·27 days ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/zeynep_weiss39 points·27 days ago

This matches my experience almost exactly on the Ozempic pens. The titration is the whole point.

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u/ffmi_watcherOP-16 points·27 days ago

I did the fast version. 2.4mg to 2.5mg in 22 weeks. Spent a weekend learning why the schedule exists.

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u/noor_hovland1 point·26 days ago

I did the fast version.

Yes, exactly this, and it is the bit that took me 33 weeks to accept.

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u/joaquin_stanescu1 point·27 days ago·edited

Is that purity or net peptide content? They are not the same number.

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u/endpoint_creep1 point·26 days ago

week 87 and i am still not at maintenance, do not rush the ladder

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u/ahmed_abubakar1 point·26 days ago·edited

my ApoB moved before the scale did and i nearly missed it

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u/greta_perrin21 points·27 days ago

stalled at 1.0mg, went up, and regretted it, the stall would have broken anyway

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u/kenji_demir23 points·27 days ago

Are you on a pen or research vial? Because the trajectory is different.

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u/hassan_ostergaard22 points·26 days ago·edited

titration speed is weekly dosing plus side effects, period

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[deleted]9 points·26 days ago

[deleted]

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u/test_it_yourselfvetting2 points·26 days ago

my TSH moved before the scale did and i nearly missed it

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u/units_not_mgsyringe math5 points·26 days ago

[deleted]

Yes, exactly this, and it is the bit that took me 94 weeks to accept.

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u/ffmi_watcherOP17 points·26 days ago

the 2.4mg dose is not the target, it is just what the pen goes up to

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Everything semaglutide: branded pens, compounded vials, oral formulations and the research-grade material people reconstitute themselves. Titration schedules, side-effect management, plateau troubleshooting and long-term maintenance. Dose questions are welcome; "what dose should I take" answers are not, because nobody here is your prescriber.

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