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264
c/semaglutide·posted 8 days ago by u/leila_silva

week 2 and literally nothing has happened, is this normal

Titration Cold Box ×2

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking 2.4mg against eGFR for 7 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

401 up / 137 down75% upvoted20 commentsid 1ci0yw22 Jul 2026

20 comments

16 in this archive, depth 5

best — the order this archive was captured in

u/b12_baseline40 points·7 days ago

Not convinced. The evidence does not support that reading.

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u/leila_vasquez47 points·7 days ago

the sulphur burps passes. i promise. not medical advice.

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u/joaquin_stanescu29 points·6 days ago

week 2 on the pen, 5kg down, this is the answer

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u/hassan_ostergaard14 points·6 days ago

How long were you at 5mg before you moved up?

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u/camila_mensa22 points·7 days ago

Not convinced.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/plain_titration17 points·7 days ago

week 9 and i am still not at maintenance, do not rush the ladder

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u/joaquin_stanescu6 points·7 days ago

Small correction: the trial was 5 weeks, not 4. Does not change your point but people will quote it.

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u/elodie_grimaldi25 points·7 days ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/ffmi_watcher20 points·7 days ago

okay but what dose of sema are you on

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u/marit_coelho10 points·6 days ago

Disagree. What you are describing is consistent with 2.4mg, not with what you concluded.

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[deleted]7 points·6 days ago

[deleted]

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u/plain_titration2 points·6 days ago

This matches my experience almost exactly on the Ozempic pens. The titration is the whole point.

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u/rina_bergstrom-32 points·7 days ago

the quiet is real. the food noise just stops.

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u/nausea_notesside effects17 points·7 days ago

stalled at 0.25mg, went up, and regretted it, the stall would have broken anyway

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u/throwaway_titration5 points·7 days ago

my A1c moved before the scale did and i nearly missed it

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u/adaeze_brandt6 points·7 days ago

week 55 and i am still not at maintenance, do not rush the ladder

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Everything semaglutide: branded pens, compounded vials, oral formulations and the research-grade material people reconstitute themselves. Titration schedules, side-effect management, plateau troubleshooting and long-term maintenance. Dose questions are welcome; "what dose should I take" answers are not, because nobody here is your prescriber.

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