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c/glp1science·posted 2 years ago by u/laila_almeida

[Discussion] can we stop arguing about appetite until somebody posts a number

Discussion Long Haul ×5 Slow Clap ×3

Genuinely asking, not being difficult.

Everyone in c/tapering repeats that half-life is important. I believe it, but I have never seen anyone show why, and when I search I get 19 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

2,840 up / 658 down81% upvoted42 commentsid 1x5mrv2 Feb 2024

42 comments

7 in this archive, depth 3

best — the order this archive was captured in

u/brigade_detector418 points·2 years ago

the half-life is gastric emptying, affects steady state timing

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u/niels_roos94 points·2 years ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/wholesome_lurker336 points·2 years ago

Receptor distribution explains why early fullness hits gastric emptying but not gastric emptying.

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u/milan_mensah234 points·2 years ago

Strongly agree. Central appetite is real but people overstate it.

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u/laila_almeidaOP342 points·2 years ago

I am going to push back on this slightly.

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u/bastian_ekstrom0 points·2 years ago

I am going to push back on this slightly.

Yes, exactly this, and it is the bit that took me 58 weeks to accept.

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u/laila_almeidaOP209 points·2 years ago

Which paper are you quoting?

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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