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c/glp1science·submitted 2 years ago by u/yusuf_ramos

incretin: the version I wish someone had shown me in week 1

Discussionbranch of 5 comments

Right, the mechanism question again, but with numbers this time. I have 21 data points over 6 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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5 comments, started 2 years ago
u/the_poster_in_question_2026121 points·2 years ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/aleksi_lehtinen-3 points·2 years ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

Yes, exactly this, and it is the bit that took me 8 weeks to accept.

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u/tomas_broberg1 point·2 years ago

the 21-day half-life means week 21 is still ramp-up pharmacokinetically

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u/milan_mensah1 point·2 years ago·edited

rodent gastric emptying tells you what to investigate, not what to expect in humans

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u/ismael_chukwu141 points·2 years ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

Yes, exactly this, and it is the bit that took me 17 weeks to accept.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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