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c/glp1science·posted 1 year ago by u/annika_fonseca

[Results] 32 weeks, 31kg, and pharmacology was the hard part

Question Clean Column ×1 Sourced ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking mechanism against triglycerides for 25 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

2,557 up / 563 down82% upvoted45 commentsid 1xg4co24 Sep 2024

45 comments

18 in this archive, depth 4

best — the order this archive was captured in

u/bastian_ekstrom118 points·1 year ago
that is the funniest sentence i have read on this site
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[deleted]87 points·1 year ago

[deleted]

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u/slow_logbook81 points·1 year ago·edited

Yeah, the incretin mechanism is doing the work here.

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u/kavya_kravchenko-33 points·1 year ago

Where does the appetite data actually come from?

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u/viktor_girard82 points·1 year ago
genuine question, not being difficult: how do you know
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u/gastric_emptying_gMOD60 points·1 year ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/aksel_palacios57 points·1 year ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/camila_lindqvist42 points·1 year ago

Mechanistically the bit that matters is gastric emptying. It explains most of the early profile and a decent chunk of the outcome.

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u/yusuf_ramos12 points·1 year ago

Mechanistically the bit that matters is gastric emptying.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/amara_dziedzic27 points·1 year ago

amylin is not GLP-1, posts conflating them get corrected

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u/santiago_rasmussen13 points·1 year ago

amylin is not GLP-1, posts conflating them get corrected

Disagree on that part. 98.4% and 98.3% on the same vial is normal.

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u/analog_alphabet30 points·1 year ago

Strongly agree. Central appetite is real but people overstate it.

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u/annika_fonsecaOP22 points·1 year ago

Rodent, human, or in vitro?

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u/employer_carveout35 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/priya_guerrero28 points·1 year ago

amylin is not GLP-1, posts conflating them get corrected

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u/runa_cabrera17 points·1 year ago

rodent appetite tells you what to investigate, not what to expect in humans

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u/flair_enthusiast25 points·1 year ago

glucagon-receptor contribution is incretin for dual and triple agonism

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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