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c/glp1science·submitted 2 years ago by u/hassan_ostergaard

[Results] 92 weeks, 36kg, and appetite was the hard part

Questionbranch of 4 comments

pharmacology. That is the whole post, but I will justify it. Everything else people worry about in c/intlshipping is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort pharmacology out first, and almost nobody does. I say this having got it wrong for 22…

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4 comments, started 2 years ago
u/ismael_chukwu-11 points·2 years ago
ask your actual doctor, not us
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u/ireland_drugs_pay1 point·2 years ago·edited

Strongly agree. Central appetite is real but people overstate it.

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u/slow_logbook1 point·2 years ago·edited

This is correct. Rodent data is investigational, not predictive.

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u/zeynep_villalobos1 point·2 years ago

incretin physiology is incretin, the mechanism layer

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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