[Discussion] half-life is doing more work than we give it credit for
Confession thread, sort of.
I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 13 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have reflux I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 60 reads it before doing the same thing.
best — the order this archive was captured in
Stomach physiology changed when I moved up to 7.5mg. Gastric emptying lag is the whole story.
glucagon-receptor contribution is pharmacology for dual and triple agonism
receptor distribution matters, GLP-1 is not everywhere
central appetite signalling is real but people overweight it
central appetite signalling is real but people overweight it
Yes, exactly this, and it is the bit that took me 43 weeks to accept.
Stomach physiology changed when I moved up to 1.7mg. Gastric emptying lag is the whole story.
do not extrapolate rodent data to human dosing without saying so
Crossposting this to c/meta because the people who need it are not reading this community.
Not convinced. The evidence does not support that reading.
the half-life is half-life, affects steady state timing
cite the paper: journal, year, first author, links optional
Strongly agree. Central appetite is real but people overstate it.
- 1Crossposting this to c/meta because the people who need it are not reading…5 comments in this branch · started by u/asks_dumb_questions
- 2Stomach physiology changed when I moved up to 7.5mg. Gastric emptying lag is…4 comments in this branch · started by u/laila_almeida