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c/glp1science·submitted 2 years ago by u/flair_enthusiast

[Question] incretin — what am I missing here

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Right, the appetite question again, but with numbers this time. I have 22 data points over 34 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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4 comments, started 2 years ago
u/mod_ambulatoryadmin102 points·2 years ago

gastric emptying is real and explains most early nausea

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u/slow_logbook76 points·2 years ago·edited

Which paper are you quoting?

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u/zeynep_villalobos88 points·2 years ago

rodent gastric emptying tells you what to investigate, not what to expect in humans

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u/bastian_ekstrom44 points·2 years ago·edited

the half-life is half-life, affects steady state timing

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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