GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Archived. This submission is more than a year old. Votes and new comments are closed, and some of the advice in it may have been superseded — check the community wiki for the current version.
3.1k
c/glp1science·posted 1 year ago by u/aleksi_eriksen

my A1c moved and I cannot work out whether appetite is why

Discussion Sourced ×8 Long Haul ×3 Clean Column ×1

Week 86 update. 7kg down from the start, reflux basically gone since about week 43.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

11,693 up / 8,620 down58% upvoted33 commentsid 1yu2d512 Nov 2024

33 comments

11 in this archive, depth 4

best — the order this archive was captured in

u/nora_lundgren497 points·1 year ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

replysharereportpermalink
u/aleksi_eriksenOP224 points·1 year ago

Receptor distribution explains why injection-site soreness hits half-life but not gastric emptying.

replysharereportpermalink
u/runa_cabrera349 points·1 year ago

Respectfully this is a sample of one presented as a finding.

replysharereportpermalink
u/isabela_nilsen205 points·1 year ago

Is that mechanism or speculation?

replysharereportpermalink
u/ingrid_correia161 points·1 year ago

Is that mechanism or speculation?

Disagree on that part. 95.1% and 96.2% on the same vial is normal.

replysharereportpermalink
u/asks_dumb_questions61 points·1 year ago

mechanistic speculation is welcome if flaired as speculation

replysharereportpermalink
u/bilal_osei-29 points·1 year ago

Where does the mechanism data actually come from?

replysharereportpermalink
[deleted]1 point·1 year ago

[deleted]

replysharereportpermalink
load more comments (3) →
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/glp1science

The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

50kmembers
95submissions
Oct 2023created
submissions / month, last year
Sponsored

PeptideMeter Analytics

Independent testing plus vendor-level trend data. Community-funded, unaffiliated.

peptidemeter.com
More in c/glp1science
c/glp1science rules
  1. Cite the paper: journal, year, first author. Links optional, citation mandatory.
  2. Mechanistic speculation is welcome if flaired as speculation.
  3. No extrapolating rodent data to human dosing without saying that is what you are doing.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/incretin_ivyu/trialwatch_theou/gastric_emptying_gu/sig_figs_sam
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →