switched from 0.25mg to 15mg and the muscle cramps got better, not worse
Genuinely asking, not being difficult.
Everyone in c/tapering repeats that pharmacology is important. I believe it, but I have never seen anyone show why, and when I search I get 4 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
receptor distribution matters, GLP-1 is not everywhere
The receptor literature is interesting but rodent models do not scale linearly to human dosing.
Removed a chain here. The rule is one line long and it is not negotiable.
do not extrapolate rodent data to human dosing without saying so
Removed a chain here.
Yes, exactly this, and it is the bit that took me 9 weeks to accept.
central appetite signalling is real but people overweight it
receptor distribution matters, GLP-1 is not everywhere
do not extrapolate rodent data to human dosing without saying so
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
gastric emptying is real and explains most early nausea
Receptor distribution explains why early fullness hits gastric emptying but not mechanism.
The half-life is 11 hours, which means week 11 is genuinely still ramp-up. Week 22 is steady state.
The half-life is 11 hours, which means week 11 is genuinely still ramp-up.
Adding to this: receptor is doing more work than the comment implies.
- 1The receptor literature is interesting but rodent models do not scale…7 comments in this branch · started by u/nhs_waitlist_n