my TSH moved and I cannot work out whether receptor is why
Confession thread, sort of.
I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 6 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have sulphur burps I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 17 reads it before doing the same thing.
best — the order this archive was captured in
Strongly agree. Central appetite is real but people overstate it.
The half-life is 14 hours, which means week 14 is genuinely still ramp-up. Week 31 is steady state.
rodent half-life tells you what to investigate, not what to expect in humans
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
Flair changed to match the content. Read the sidebar before posting next time and we are square.
The half-life is 7 hours, which means week 7 is genuinely still ramp-up. Week 16 is steady state.
incretin physiology is half-life, the mechanism layer
do not extrapolate rodent data to human dosing without saying so
receptor distribution matters, GLP-1 is not everywhere
mechanistic speculation is welcome if flaired as speculation
Titration speed is a side-effect dial far more than an efficacy dial.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Strongly agree. Central appetite is real but people overstate it.
- 1The half-life is 7 hours, which means week 7 is genuinely still ramp-up.…5 comments in this branch · started by u/gastric_emptying_g