GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of what changed for me between week 95 and week 43 — 56 comments in the full submission. View in context.
3.5k
c/glp1science·submitted 2 years ago by u/employer_carveout

what changed for me between week 95 and week 43

Speculationbranch of 10 comments

Right, the mechanism question again, but with numbers this time. I have 18 data points over 18 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

Read the full submission and all 56 comments →

This branch

10 comments, started 2 years ago
u/nhs_waitlist_nUK170 points·2 years ago

amylin is not GLP-1, posts conflating them get corrected

replysharereportpermalink
u/nadia_fonseca236 points·2 years ago

This is correct. Rodent data is investigational, not predictive.

replysharereportpermalink
u/asks_dumb_questions0 points·2 years ago

Which paper are you quoting?

replysharereportpermalink
u/zeynep_villalobos79 points·2 years ago

the half-life is half-life, affects steady state timing

replysharereportpermalink
u/amara_dziedzic79 points·2 years ago

rodent mechanism tells you what to investigate, not what to expect in humans

replysharereportpermalink
u/employer_carveoutOP41 points·2 years ago

Receptor distribution explains why sulphur burps hits receptor but not pharmacology.

replysharereportpermalink
u/dose_creep_dan14 points·2 years ago·edited

receptor distribution matters, GLP-1 is not everywhere

replysharereportpermalink
u/not_my_main_nm10 points·2 years ago

do not extrapolate rodent data to human dosing without saying so

replysharereportpermalink
u/osman_eriksen4 points·2 years ago

amylin is not GLP-1, posts conflating them get corrected

replysharereportpermalink
u/camila_lindqvist-17 points·2 years ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

replysharereportpermalink

← back to the whole thread

About c/glp1science

The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

50kmembers
95submissions
Oct 2023created
submissions / month, last year
Sponsored

Janoshik Analytical

Independent HPLC and mass spec. The number you get is the number they found.

janoshik.com
Sponsored

GL Biochem (Shanghai)

Custom peptides and amino acids direct from the manufacturer since 1998. ISO 9001 / cGMP. Batch COA every order.

glbiochem.net
c/glp1science rules
  1. Cite the paper: journal, year, first author. Links optional, citation mandatory.
  2. Mechanistic speculation is welcome if flaired as speculation.
  3. No extrapolating rodent data to human dosing without saying that is what you are doing.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Moderators
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.