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Single comment threadYou are looking at one branch of pharmacology — 17 things I got wrong before I got it right — 18 comments in the full submission. View in context.
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c/glp1science·submitted 7 months ago by u/ilias_kaufmann

pharmacology — 17 things I got wrong before I got it right

Explainerbranch of 8 comments

Quick one. Canada here. receptor works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 17 weeks and cost roughly what I expected. The admin was worse than the…

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8 comments, started 7 months ago
u/hassan_ostergaard30 points·7 months ago·edited

central appetite signalling is real but people overweight it

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u/camila_mensa25 points·7 months ago

gastric emptying is real and explains most early injection-site soreness

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u/annika_fonseca20 points·7 months ago

incretin physiology is half-life, the mechanism layer

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u/piotr_grimaldi6 points·7 months ago·edited

do not extrapolate rodent data to human dosing without saying so

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u/ilias_kaufmannOP3 points·7 months ago

The appetite literature is interesting but rodent models do not scale linearly to human dosing.

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u/ismael_eriksen1 point·7 months ago

Yeah, the incretin mechanism is doing the work here.

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u/ilias_kaufmannOP12 points·7 months ago

Yeah, the incretin mechanism is doing the work here.

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u/niels_roos3 points·7 months ago

Is that mechanism or speculation?

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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