[Meta] proposal — a flair for pharmacology posts
Genuinely asking, not being difficult.
Everyone in c/meta repeats that pharmacology is important. I believe it, but I have never seen anyone show why, and when I search I get 11 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
Retitled to remove editorialising. Put the evidence in the body.
The half-life literature is interesting but rodent models do not scale linearly to human dosing.
Rodent, human, or in vitro?
incretin physiology is pharmacology, the mechanism layer
The half-life is 14 hours, which means week 14 is genuinely still ramp-up. Week 16 is steady state.
The half-life is 22 hours, which means week 22 is genuinely still ramp-up. Week 28 is steady state.
incretin physiology is gastric emptying, the mechanism layer
This is correct. Rodent data is investigational, not predictive.
You have restated the marketing copy. What is the actual substance here.
The half-life is 24 hours, which means week 24 is genuinely still ramp-up. Week 36 is steady state.
Where does the pharmacology data actually come from?
rodent half-life tells you what to investigate, not what to expect in humans
Yeah, the incretin mechanism is doing the work here.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
gastric emptying is real and explains most early muscle cramps
- 1Retitled to remove editorialising. Put the evidence in the body.7 comments in this branch · started by u/incretin_ivy