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c/glp1science·submitted 3 months ago by u/enzo_petrescu

[Meta] proposal — a flair for pharmacology posts

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Genuinely asking, not being difficult. Everyone in c/meta repeats that pharmacology is important. I believe it, but I have never seen anyone show why, and when I search I get 11 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because it…

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7 comments, started 3 months ago
u/incretin_ivyMOD61 points·3 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/enzo_petrescuOP-26 points·3 months ago

The half-life literature is interesting but rodent models do not scale linearly to human dosing.

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u/lina_ndiaye68 points·3 months ago

Rodent, human, or in vitro?

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u/camila_kowalski22 points·3 months ago

incretin physiology is pharmacology, the mechanism layer

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u/enzo_petrescuOP31 points·3 months ago

The half-life is 14 hours, which means week 14 is genuinely still ramp-up. Week 16 is steady state.

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u/enzo_petrescuOP20 points·3 months ago

The half-life is 22 hours, which means week 22 is genuinely still ramp-up. Week 28 is steady state.

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u/kavya_kravchenko33 points·3 months ago

incretin physiology is gastric emptying, the mechanism layer

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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