Single comment threadYou are looking at one branch of receptor: what the trials say vs what this community says — 43 comments in the full submission. View in context.
1k
receptor: what the trials say vs what this community says
Right, the mechanism question again, but with numbers this time. I have 2 data points over 40 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…
The half-life is 6 hours, which means week 6 is genuinely still ramp-up. Week 14 is steady state.
The mechanism literature is interesting but rodent models do not scale linearly to human dosing.
The appetite literature is interesting but rodent models do not scale linearly to human dosing.
gastric emptying is real and explains most early nausea
the 7-day half-life means week 7 is still ramp-up pharmacokinetically