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c/glp1science·submitted 2 months ago by u/incretin_ivy

help me understand incretin, I have read the wiki twice

Questionbranch of 7 comments

Trying to settle this properly because the thread from last year went in circles. The claim: mechanism matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 13 months without either producing anything. What would actually settle it is 11 people measuring the same…

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7 comments, started 2 months ago
u/gustav_vermeulen250 points·2 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/incretin_ivyOPpharmacology105 points·2 months ago

Stomach physiology changed when I moved up to 2.4mg. Gastric emptying lag is the whole story.

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u/rina_bergstrom142 points·2 months ago

do not extrapolate rodent data to human dosing without saying so

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u/split_dose_sceptic0 points·2 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/karma_irrelevant66 points·2 months ago

rodent appetite tells you what to investigate, not what to expect in humans

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[removed]48 points·2 months ago

[removed by moderator]

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u/georgi_chowdhury38 points·2 months ago

Where does the appetite data actually come from?

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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