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c/glp1science·submitted 2 months ago by u/incretin_ivy

help me understand incretin, I have read the wiki twice

Questionbranch of 5 comments

Trying to settle this properly because the thread from last year went in circles. The claim: mechanism matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 13 months without either producing anything. What would actually settle it is 11 people measuring the same…

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5 comments, started 2 months ago
u/hassan_ostergaard121 points·2 months ago

Strongly agree. Central appetite is real but people overstate it.

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u/fatima_kowalski100 points·2 months ago

Strongly agree.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/annika_fonseca56 points·2 months ago

glucagon-receptor contribution is mechanism for dual and triple agonism

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u/farid_kuipers19 points·2 months ago·edited

rodent gastric emptying tells you what to investigate, not what to expect in humans

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u/nadia_bakker42 points·2 months ago

rodent pharmacology tells you what to investigate, not what to expect in humans

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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