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c/glp1science·submitted 1 year ago by u/gustav_vermeulen

does mechanism actually matter or is it forum lore at this point

Questionbranch of 6 comments

Posting this because I searched for it and got nothing useful. Setup: 12.5mg, week 36, constipation present but not ruining anything. I changed exactly one variable — receptor — and tracked it for 19 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I…

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6 comments, started 1 year ago
u/annika_fonseca21 points·1 year ago

the 22-day half-life means week 22 is still ramp-up pharmacokinetically

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u/nhs_waitlist_nUK30 points·1 year ago

the 22-day half-life means week 22 is still ramp-up pharmacokinetically

Adding to this: receptor is doing more work than the comment implies.

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u/marisol_kravchenko11 points·1 year ago

mechanistic speculation is welcome if flaired as speculation

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u/gustav_vermeulenOP6 points·1 year ago

Stomach physiology changed when I moved up to 0.5mg. Gastric emptying lag is the whole story.

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u/second_week_sceptic31 points·1 year ago

Is that mechanism or speculation?

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u/cato_batista0 points·1 year ago

Strongly agree. Central appetite is real but people overstate it.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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