does mechanism actually matter or is it forum lore at this point
Posting this because I searched for it and got nothing useful.
Setup: 12.5mg, week 36, constipation present but not ruining anything. I changed exactly one variable — receptor — and tracked it for 19 weeks.
Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.
Not medical advice, obviously. This is one person with a spreadsheet.
best — the order this archive was captured in
the half-life is appetite, affects steady state timing
the half-life is appetite, affects steady state timing
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
This is correct. Rodent data is investigational, not predictive.
This is correct.
Adding to this: incretin is doing more work than the comment implies.
Is that mechanism or speculation?
gastric emptying is real and explains most early reflux
do not extrapolate rodent data to human dosing without saying so
Stomach physiology changed when I moved up to 1.7mg. Gastric emptying lag is the whole story.
the 22-day half-life means week 22 is still ramp-up pharmacokinetically
the 22-day half-life means week 22 is still ramp-up pharmacokinetically
Adding to this: receptor is doing more work than the comment implies.
mechanistic speculation is welcome if flaired as speculation
Stomach physiology changed when I moved up to 0.5mg. Gastric emptying lag is the whole story.
Strongly agree. Central appetite is real but people overstate it.
The gastric emptying literature is interesting but rodent models do not scale linearly to human dosing.
gastric emptying is real and explains most early fatigue
- 1the 22-day half-life means week 22 is still ramp-up pharmacokinetically6 comments in this branch · started by u/annika_fonseca
- 2Is that mechanism or speculation?4 comments in this branch · started by u/employer_carveout