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c/glp1science·posted 3 months ago by u/ferran_batista

[Discussion] the incretin advice in here is 14 years out of date

Discussion

I have had 8 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 18 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 96.8% against a claimed 99.1%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

109 up / 36 down75% upvoted11 commentsid y80soe24 Apr 2026

11 comments

11 in this archive, depth 4

best — the order this archive was captured in

u/isabela_nilsen16 points·3 months ago

Half-life is about 168 hours, so steady state lands around week 10–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/incretin_ivyMOD8 points·3 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/bilal_osei13 points·3 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/kian_balogun9 points·3 months ago
source?
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u/farid_kuipers7 points·3 months ago

rodent pharmacology tells you what to investigate, not what to expect in humans

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u/lurker_for_years4 points·3 months ago

incretin physiology is appetite, the mechanism layer

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u/sig_figs_sammod · analytical7 points·3 months ago

source?

Disagree on that part. 97.4% and 98.3% on the same vial is normal.

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u/vikram_mbeki13 points·3 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/ferran_batistaOP7 points·3 months ago

receptor distribution matters, GLP-1 is not everywhere

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u/ferran_batistaOP7 points·3 months ago

Stomach physiology changed when I moved up to 2.4mg. Gastric emptying lag is the whole story.

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u/ferran_batistaOP4 points·3 months ago

Stomach physiology changed when I moved up to 10mg. Gastric emptying lag is the whole story.

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About c/glp1science

The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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