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c/glp1science·submitted 4 months ago by u/hedda_adeyemi

unpopular opinion: gastric emptying is massively overrated

Questionbranch of 8 comments

Genuinely asking, not being difficult. Everyone in c/tapering repeats that gastric emptying is important. I believe it, but I have never seen anyone show why, and when I search I get 4 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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8 comments, started 4 months ago
u/formulary_fighterappeals26 points·4 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/amara_dziedzic6 points·4 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/camila_lindqvist21 points·4 months ago·edited

Respectfully this is a sample of one presented as a finding.

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u/ireland_drugs_pay6 points·4 months ago

rodent half-life tells you what to investigate, not what to expect in humans

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u/emeka_chowdhury4 points·4 months ago

Rodent, human, or in vitro?

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u/aa_analysis_andy3 points·4 months ago

This is correct. Rodent data is investigational, not predictive.

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u/gradient_goblin1 point·4 months ago

mechanistic speculation is welcome if flaired as speculation

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u/hedda_adeyemiOP21 points·4 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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