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c/glp1science·posted 8 months ago by u/ismael_eriksen

[Results] 11 weeks on 2.5mg, full numbers, ask me anything boring

Speculation Receipts ×4 Clean Column ×2

Right, the receptor question again, but with numbers this time.

I have 12 data points over 12 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 92, not week 46. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

2,629 up / 249 down91% upvoted42 commentsid z1eh5p1 Dec 2025

42 comments

6 in this archive, depth 2

best — the order this archive was captured in

u/georgi_chowdhury513 points·7 months ago

cite the paper: journal, year, first author, links optional

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u/yannick_barros-10 points·7 months ago

The pharmacology literature is interesting but rodent models do not scale linearly to human dosing.

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u/bastian_eriksen181 points·8 months ago

the half-life is incretin, affects steady state timing

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u/trialwatch_theoMOD96 points·7 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/camila_mensa114 points·7 months ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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About c/glp1science

The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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