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c/hplc·submitted 8 months ago by u/ferran_krastev

[Question] New Zealand — has anyone got a straight answer on LC-MS

Questionbranch of 6 comments

method development. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort method development out first, and almost nobody does. I say this having got it wrong…

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6 comments, started 7 months ago
u/fatima_yildiz234 points·7 months ago

Yeah, the chromatogram profile matters more than the headline number.

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u/hplc_hobbyistMOD125 points·7 months ago·edited

Retitled to remove editorialising. Put the evidence in the body.

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[removed]59 points·7 months ago

[removed by moderator]

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u/lina_novak80 points·7 months ago

a round-robin on baseline integration would be genuinely useful

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u/downvote_magnet18 points·7 months ago

area% and mass% are not the same and this whole post conflates them

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u/ferran_krastevOP32 points·7 months ago

Strongly agree. Largest single impurity tells a different story than total purity.

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