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c/semaglutide·posted 1 year ago by u/quiet_moderator

nobody warned me about constipation and I would have liked the warning

Titration Long Haul ×6 Sourced ×1 Well Actually ×1

Confession thread, sort of.

I went from 1.7mg to 0.25mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 22 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have sulphur burps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 29 reads it before doing the same thing.

8,114 up / 403 down95% upvoted39 commentsid 1c38iq24 Nov 2024

39 comments

17 in this archive, depth 4

best — the order this archive was captured in

u/joaquin_stanescu812 points·1 year ago

Mechanistically the bit that matters is titration. It explains most of the early profile and a decent chunk of the outcome.

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u/plain_titration475 points·1 year ago

Did you time the injection consistently each week or was it more ad hoc?

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u/lane_map_larrylogistics152 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/vikram_mbeki39 points·1 year ago

nope, 0.25 counts, it is just not the dose most people stay on

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u/ravi_sandvik26 points·1 year ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/rania_diallo13 points·1 year ago

nope, 0.25 counts, it is just not the dose most people stay on

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u/runa_wikstrom286 points·1 year ago·edited

the 2.4mg dose is not the target, it is just what the pen goes up to

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u/quiet_moderatorOPmod204 points·1 year ago

the 2.4mg dose is not the target, it is just what the pen goes up to

Yes, exactly this, and it is the bit that took me 29 weeks to accept.

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u/quiet_moderatorOPmod-31 points·1 year ago

Week 23 for me and the honest summary is: 22kg down, constipation manageable, and the quiet happened around week 19.

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u/ffmi_watcher276 points·1 year ago

the the food-noise thing passes. i promise. not medical advice.

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u/quiet_moderatorOPmod404 points·1 year ago

Tried the split-dose thing for 9 weeks. Felt slightly smoother, lost at exactly the same rate. Went back to weekly.

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u/kenji_demir180 points·1 year ago

Hard agree. Week 39 me needed this. Week 82 me is nodding smugly.

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u/zeynep_weiss71 points·1 year ago

week 33 on the pen, 17kg down, this is the answer

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u/bilal_osei119 points·1 year ago

Kept a public log for 83 weeks. The comments are what kept it going, honestly. Accountability from strangers works.

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u/nausea_notesside effects37 points·1 year ago

stalled at 7.5mg, went up, and regretted it, the stall would have broken anyway

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u/arne_restrepo98 points·1 year ago·edited

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/diego_sorensen224 points·1 year ago·edited

My early fullness was worst at 1.0mg and better at 1.7mg, which makes no sense and I have stopped trying to explain it.

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Everything semaglutide: branded pens, compounded vials, oral formulations and the research-grade material people reconstitute themselves. Titration schedules, side-effect management, plateau troubleshooting and long-term maintenance. Dose questions are welcome; "what dose should I take" answers are not, because nobody here is your prescriber.

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