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c/semaglutide·posted 1 year ago by u/coa_janitor

unpopular opinion: semaglutide is massively overrated

Question Well Actually ×4

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking semaglutide against triglycerides for 27 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

471 up / 152 down76% upvoted17 commentsid 1eb8hs3 Feb 2025

17 comments

17 in this archive, depth 5

best — the order this archive was captured in

u/bilal_osei32 points·1 year ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/leila_silva22 points·1 year ago
it is in the wiki actually
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u/viktor_nkemelu18 points·1 year ago

Hard agree. Week 30 me needed this. Week 76 me is nodding smugly.

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u/coa_janitorOPmod · c/coa-38 points·1 year ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/niels_lindqvist1 point·1 year ago

nope, 0.25 counts, it is just not the dose most people stay on

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u/careful_gradient_again1 point·1 year ago

week 37 and i am still not at maintenance, do not rush the ladder

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u/archived_thread_a1 point·1 year ago

okay but what dose of sema are you on

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[deleted]6 points·1 year ago

[deleted]

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u/tomas_kimani4 points·1 year ago

That is net peptide content, not purity. Different number, different meaning.

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u/rina_bergstrom2 points·1 year ago

pens are overpriced, research vials are research grade, same molecule different price

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u/nausea_notesMOD12 points·1 year ago

Tracking number removed. It identifies both ends of a shipment.

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u/coa_janitorOPmod · c/coa5 points·1 year ago

Stalled at 1.0mg, changed nothing, and it started moving again on week 40. Very nearly went up. Glad I did not.

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u/freya_baptista2 points·1 year ago

my eGFR moved before the scale did and i nearly missed it

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u/diego_sorensen10 points·1 year ago

I am going to push back on this slightly.

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u/ismael_chukwu3 points·1 year ago

Cosigning. The slow route gets the outcome, the fast route gets you the side effects.

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u/oskar_kaufmann6 points·1 year ago

New Zealand here. Waited 8 months on an NHS list, gave up, went private, and the cost was half what I expected but the admin was worse.

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u/enzo_danquah1 point·1 year ago

I did the fast version. 10mg to 7.5mg in 6 weeks. Spent a weekend learning why the schedule exists.

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Everything semaglutide: branded pens, compounded vials, oral formulations and the research-grade material people reconstitute themselves. Titration schedules, side-effect management, plateau troubleshooting and long-term maintenance. Dose questions are welcome; "what dose should I take" answers are not, because nobody here is your prescriber.

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