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c/semaglutide·posted 2 years ago by u/gradient_goblin

[Discussion] the 2.4mg advice in here is 16 years out of date

Discussion Clean Column ×8 Well Actually ×1 Slow Clap ×3

Been lurking in c/survodutide for about 12 months and finally have something worth posting.

Short version: week 38, 1.0mg, and food noise is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 15 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 44.

14,869 up / 5,509 down73% upvoted64 commentsid 8g60qv5 Oct 2023

64 comments

30 in this archive, depth 4

best — the order this archive was captured in

u/units_not_mgMOD1.3k points·2 years ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/hassan_castellanos1k points·2 years ago

titration speed is food noise plus side effects, period

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[deleted]734 points·2 years ago

[deleted]

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u/chidi_demir730 points·2 years ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/gradient_goblinOP1k points·2 years ago

Stalled at 7.5mg, changed nothing, and it started moving again on week 75. Very nearly went up. Glad I did not.

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u/zeynep_weiss-7 points·2 years ago

the 2.4mg dose is not the target, it is just what the pen goes up to

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u/wanjiru_varga322 points·2 years ago

week 65 and i am still not at maintenance, do not rush the ladder

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u/sofia_wikstrom0 points·2 years ago

nope, 0.25 counts, it is just not the dose most people stay on

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u/hassan_castellanos1 point·2 years ago·edited

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/marta_trevino334 points·2 years ago

Slight fix: the number was 96.8, not 97.4. Decimal point, but a fairly consequential one.

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u/wanjiru_varga227 points·2 years ago

How long were you at 7.5mg before you moved up?

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u/endpoint_creep960 points·2 years ago

the quiet is real. the food noise just stops.

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u/vikram_mbeki542 points·2 years ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/camila_mensa161 points·2 years ago

stalled at 2.5mg, went up, and regretted it, the stall would have broken anyway

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u/iman_falk100 points·2 years ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/leila_vasquez256 points·2 years ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/hamza_weiss359 points·2 years ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/kenji_demir297 points·2 years ago

week 43 and i am still not at maintenance, do not rush the ladder

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u/gradient_goblinOP163 points·2 years ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

Yes, exactly this, and it is the bit that took me 49 weeks to accept.

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u/greta_perrin339 points·2 years ago·edited

I am going to push back on this slightly.

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u/leila_vasquez281 points·2 years ago

Did anything else change in the same window? Sleep, protein, steps, anything?

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u/georgi_haddad0 points·2 years ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/oskar_ibarra275 points·2 years ago·edited

week 89 and i am still not at maintenance, do not rush the ladder

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u/zofia_lindholm183 points·2 years ago

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

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u/leila_silva91 points·2 years ago

Not convinced. The evidence does not support that reading.

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u/viktor_nkemelu132 points·2 years ago

stalled at 12.5mg, went up, and regretted it, the stall would have broken anyway

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u/kenji_vasquez86 points·2 years ago
reading this at 2am on my 26th week. thank you.
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u/marta_trevino30 points·2 years ago

Slight fix: the number was 99.3, not 93.7. Decimal point, but a fairly consequential one.

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u/diego_sorensen50 points·2 years ago

my eGFR moved before the scale did and i nearly missed it

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