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c/t2dglp1·posted 2 months ago by u/joaquin_trevino

20 months in and A1c is still the thing I get wrong

Discussion Cold Box ×8 The Quiet One ×3

I have had 2 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 22 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 99.0% against a claimed 98.0%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

1,609 up / 553 down74% upvoted34 commentsid 1sut7c26 May 2026

34 comments

23 in this archive, depth 5

best — the order this archive was captured in

u/source_or_silence137 points·2 months ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/tomas_kimani87 points·2 months ago

metformin combo is standard

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u/tomas_kimani37 points·2 months ago

A1c, CGM, stacking with metformin

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u/rui_only_ro113 points·2 months ago

post A1c with units and assay date

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u/fasting_insulin_f54 points·2 months ago

Yeah, glycaemic control is the original use.

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u/marisol_moreau0 points·2 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/joaquin_trevinoOP1 point·2 months ago

hypoglycaemia risk when stacked with A1c

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u/joaquin_trevinoOP1 point·2 months ago

Stalled for 14 weeks, changed nothing, and it started moving again on week 70.

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u/arne_amankwah1 point·2 months ago

CGM traces tell a story, numbers alone do not

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u/marta_trevino1 point·2 months ago

Second this question. I have wondered about CGM for 3 months and never seen a straight answer.

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u/joaquin_trevinoOP1 point·2 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/sock_puppet_spotter1 point·2 months ago

type 2 is the indication, weight loss is the side effect

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u/teodor_duarte66 points·2 months ago·edited

Mechanistically the bit that matters is A1c. It explains most of the early profile and a decent chunk of the outcome.

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u/amylin_amyamylin25 points·2 months ago

Strongly agree. A1c matters as much as weight.

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[deleted]9 points·2 months ago

[deleted]

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u/iman_castellanos42 points·2 months ago

Which country? Half the answers in this thread only apply in Germany.

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u/zaid_dahlberg19 points·2 months ago·edited

the 83 A1c trend is the answer

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u/fabio_lehtinen50 points·2 months ago

Slight fix: the number was 96.8, not 99.1. Decimal point, but a fairly consequential one.

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u/a1c_arcT2D17 points·2 months ago

the 37 A1c trend is the answer

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u/osman_ferrari28 points·2 months ago

type 2 is the indication, weight loss is the side effect

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u/protein_first_pnutrition0 points·2 months ago·edited

the 44 A1c trend is the answer

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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  1. Insulin and sulfonylurea interactions are a real hypo risk. Do not hand-wave them.
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