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c/t2dglp1·posted 2 years ago by u/iman_castellanos

my ALT moved and I cannot work out whether T2D is why

Discussion Cold Box ×4 Well Actually ×2

Been lurking in c/cryptopay for about 24 months and finally have something worth posting.

Short version: week 5, 7.5mg, and metformin is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 27 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 94.

2,810 up / 311 down90% upvoted33 commentsid u5u9mr30 Jul 2024

33 comments

17 in this archive, depth 5

best — the order this archive was captured in

u/hassan_ostergaard148 points·1 year ago

Yeah, glycaemic control is the original use.

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u/enzo_danquah38 points·1 year ago

Mechanistically the bit that matters is A1c. It explains most of the early profile and a decent chunk of the outcome.

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u/gentle_correctionMOD137 points·1 year ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/iman_castellanosOP70 points·1 year ago

Sweden here. Waited 10 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/georgi_haddad55 points·1 year ago

no medication-stopping advice, ever

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u/osman_ferrari104 points·1 year ago

Week 24 for me and the honest summary is: 14kg down, nausea manageable, and I have thought about food maybe four times today.

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u/arne_nyberg82 points·1 year ago

metformin combo is standard

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u/nadia_norgaard22 points·1 year ago

metformin combo is standard

Adding to this: metformin is doing more work than the comment implies.

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u/nadia_norgaard43 points·1 year ago

This is correct. Hypo risk is real.

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u/camila_sandvik86 points·1 year ago

the 44 A1c trend is the answer

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u/freya_onwuka44 points·1 year ago

the 33 A1c trend is the answer

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u/lucia_balogun32 points·1 year ago·edited

This is correct. Hypo risk is real.

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u/milan_chukwu21 points·1 year ago·edited

I am going to push back on this slightly.

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u/source_or_silence29 points·1 year ago

glycaemic control first, that is the original indication

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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