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c/t2dglp1·submitted 1 year ago by u/fabio_lehtinen

[Discussion] we are measuring T2D at the wrong time and calling it noise

Discussionbranch of 5 comments

Posting this because I searched for it and got nothing useful. Setup: 2.5mg, week 42, sulphur burps present but not ruining anything. I changed exactly one variable — metformin — and tracked it for 24 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I…

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5 comments, started 1 year ago
u/bianca_dziedzic228 points·1 year ago

Genuine question — what concentration were you at?

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u/britt_abubakar58 points·1 year ago·edited

Strongly agree. A1c matters as much as weight.

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[removed]83 points·1 year ago

[removed by moderator]

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u/runa_grimaldi104 points·1 year ago·edited

Genuine question — what concentration were you at?

Yes, exactly this, and it is the bit that took me 39 weeks to accept.

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u/arne_nyberg58 points·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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